EMD-73485

Single-particle
3.76 Å
EMD-73485
3D View Gallery
Deposition: 21/10/2025
Map released: 19/08/2026
Last modified: 19/08/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-73485

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Focused refinement map on N-terminal half of LRRK2 bound to GMPPNP (active)

EMD-73485

Single-particle
3.76 Å
EMD-73485
3D View Gallery
Deposition: 21/10/2025
Map released: 19/08/2026
Last modified: 19/08/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Leucine Rich repeat kinase 2 bound to GMP-PNP

Deposition Authors: Villagran Suarez A, Bodrug T, Leschziner A
The structural basis for LRRK2's activation and autoinhibition
Villagran Suarez A, Hatch KS, Bodrug T, Gai W, Surridge KJ, Moussikhina E, Nguyen KH, Sanz-Murillo M, Callahan R, Xiong E, Ramos D, Zhu L, Dederer V, Mathea S, Iwasa J, Knapp S, Shokat KM, Reck-Peterson SL, Leschziner AE
(2026) Cell
DOI: doi:10.1016/j.cell.2026.07.027
ISSN: 0092-8674
ASTM: CELLB5
Grant Support: