Skip to main content

EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:
Research:
perform basic research in molecular biology
Services:
offer vital services to scientists in the member states
Training
scientists, students and visitors at all levels
Transfer
and development of technology
Develop
new instruments and methods
Integrating
life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

  • EMBL
  • Barcelona
  • Hamburg
  • Heidelberg
  • Grenoble
  • Rome
  • Search
  • About us
  • Training
  • Research
  • Services
  • EMBL-EBI
Electron Microscopy Data Bank
Enter your search term(s) in the box below or build an advanced search query

Examples: 1001, Apoferritin, Tomography, Rossmann MG, 5A1A

advanced search

  • Home
  • Deposition
    • Deposit to EMDB
    • Deposit to EMPIAR
    • Guidance
      • Depositing composite maps to EMDB
  • Documentation
  • Resources
  • FTP Archive
  • REST API
  • About
  • Feedback
  • Share
    • Documentation
    • Resources
    • Deposition
      • Deposit to EMDB
      • Deposit to EMPIAR
    • FTP Archive
    • REST API
    • About
    • Feedback
    • Share

EMD-72964

Single-particle
2.69 Å
EMD-72964
3D View Gallery
Deposition: 30/09/2025
Map released: 04/02/2026
Last modified: 04/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-72964
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9yha summary report (pdf.gz) Map and 9yha FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of IDH1 R132H

EMD-72964

Single-particle
2.69 Å
EMD-72964
3D View Gallery
Deposition: 30/09/2025
Map released: 04/02/2026
Last modified: 04/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Human isocitrate dehydrogenase 1 R132H mutant
Fitted models: 9yha

Deposition Authors: Hu L , Seo H-S, Dhe-Paganon S , Berezuk AM, Tuttle KS, Zhu X, Subramaniam S, Wu X
Autopalmitoylation of IDH1-R132H regulates its neomorphic activity in cancer cells.
Hu L , Lin J, Sun L , Berezuk AM, Tuttle KS, Zhu X, Seo HS , Dhe-Paganon S , Li P, Sun Y, Ni L, Zhang J, Tan D, Wakimoto H , Cahill DP, Bai X , Luo X , Asara JM , Subramaniam S, Shan Y , Wu X
(2026) Nat Chem Biol
PUBMED: 41530531
DOI: doi:10.1038/s41589-025-02131-8
ISSN: 1552-4469
Grant Support:
  • Canada Excellence Research Chair Award: (Canada)
×

Searching in EMDBHelp

Field:
Search Filter
×

Share EMDB
EMDB
is a member of
wwPDB wwPDB Foundation
Licensing
Data preservation
EMBL-EBI

EMBL-EBI

Intranet for staff
Services
  • By topic
  • By name (A-Z)
  • Help & Support
Research
  • Publications
  • Research groups
  • Postdocs & PhDs
Training
  • Train at EBI
  • Train outside EBI
  • Train online
  • Contact organisers
Industry
  • Members Area
  • Workshops
  • SME Forum
  • Contact Industry programme
About
  • Contact us
  • Events
  • Jobs
  • News
  • People & groups

EMBL-EBI, Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK. +44 (0)1223 49 44 44

Copyright © EMBL 2019 | EMBL-EBI is part of the European Molecular Biology Laboratory | Terms of use