EMD-72760

Single-particle
2.94 Å
EMD-72760
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Deposition: 18/09/2025
Map released: 04/02/2026
Last modified: 04/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-72760
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9yc5 summary report (pdf.gz) Map and 9yc5 FULL report (pdf.gz)
EMICSS annotations (xml)

Human uPAR bound to the Fab fragment of targeted cancer therapeutic antibody FL1

EMD-72760

Single-particle
2.94 Å
EMD-72760
3D View Gallery
Deposition: 18/09/2025
Map released: 04/02/2026
Last modified: 04/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Mus musculus
Sample: Binary complex of human uPAR and Fab fragment of anti-uPAR antibody FL1
Fitted models: 9yc5

Deposition Authors: Anane RF , Whisstock JC, Engelholm LH , Law RHP, Ploug M
Structural basis for uPAR binding to an antibody developed for targeted cancer therapy. Mechanistic insights into flexibility, ligand recognition, and molecular imaging.
Anane RF , Kumari A, Venugopal H, Trepout S, Whisstock JC, Engelholm LH , Law RHP, Ploug M
(2026) Protein Sci , 35 , e70473 - e70473
PUBMED: 41575054
DOI: doi:10.1002/pro.70473
ISSN: 1469-896X
ASTM: PRCIEI