EMD-72491
V-shaped (channel-formed), ATP-bound, VX809-bound conformation of wild-type human CFTR (sharpened WalkerB2 local refinement map from cryoSPARC)
EMD-72491
Single-particle3.34 Å
Deposition: 03/09/2025Map released: 09/09/2026
Last modified: 09/09/2026
Sample Organism:
Homo sapiens
Sample: Wild-type human CFTR solubilized in digitonin and cholesterol-hemisuccinate in the presence of 2 mM MgATP
Deposition Authors: Hunt JF
,
Paige AS ,
Baranwal J ,
Cohen BM ,
Goldberg PM ,
Wang C ,
Loughlin BJ ,
Kappes JC ,
Yang Z ,
Jiang F ,
Govaerts C ,
Overtus M ,
Rich Z
Sample: Wild-type human CFTR solubilized in digitonin and cholesterol-hemisuccinate in the presence of 2 mM MgATP
Deposition Authors: Hunt JF
,
Paige AS ,
Baranwal J ,
Cohen BM ,
Goldberg PM ,
Wang C ,
Loughlin BJ ,
Kappes JC ,
Yang Z ,
Jiang F ,
Govaerts C ,
Overtus M ,
Rich Z
Nanobody-Driven Stabilization Synergistically Rescues F508del-CFTR and Reveals an Alternative Active State of the Channel
Hunt JF ,
Paige AS ,
Baranwal J ,
Cohen BM ,
Goldberg PM ,
Wang C ,
Loughlin BJ ,
Kappes JC ,
Yang Z ,
Jiang F ,
Govaerts C ,
Overtus M ,
Rich Z
To Be Published
,
Paige AS ,
Baranwal J ,
Cohen BM ,
Goldberg PM ,
Wang C ,
Loughlin BJ ,
Kappes JC ,
Yang Z ,
Jiang F ,
Govaerts C ,
Overtus M ,
Rich Z
To Be Published
Grant Support: