EMD-72399

Single-particle
6.18 Å
EMD-72399
3D View Gallery
Deposition: 29/08/2025
Map released: 30/09/2026
Last modified: 30/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-72399

Archive Files (Depositor)

Primary 3D volume (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9y1n summary report (pdf.gz) Map-9y1n FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

Cryo EM Structure of Full lengthmGluR8 Bound to Agonist L-AP4 and PAM VU6005649 in complex with G proteins

EMD-72399

Single-particle
6.18 Å
EMD-72399
3D View Gallery
Deposition: 29/08/2025
Map released: 30/09/2026
Last modified: 30/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Mus musculus
Sample: Metabotropic Glutamate receptor bound to G proteins alpha i-1, beta-1, and gamma-2 in the presence of agonist and PAM and scFv14
Fitted models: 9y1n

Deposition Authors: Marx DC, Levitz JT
Structural basis of active state coupling of metabotropic glutamate receptor 8 to beta-arrestins.
Marx DC, Huynh K, Gonzalez-Hernandez AJ, Strauss A, Rico C, Gallo PN, Sharghi Moshtaghin S, Arefin A, Broichhagen J, Eliezer D, Khelashvili G, Levitz J
(2026) Nat Commun , 17
PUBMED: 42722693
DOI: doi:10.1038/s41467-026-77556-3
ISSN: 2041-1723