EMD-72385

Single-particle
2.58 Å
EMD-72385
3D View Gallery
Deposition: 28/08/2025
Map released: 29/04/2026
Last modified: 12/08/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-72385

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9y05 summary report (pdf.gz) Map-9y05 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of human VCP/p97-R89W mutant bound to CB-5083

EMD-72385

Single-particle
2.58 Å
EMD-72385
3D View Gallery
Deposition: 28/08/2025
Map released: 29/04/2026
Last modified: 12/08/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: VCP/p97 R89W mutant bound to CB-5083
Fitted models: 9y05

Deposition Authors: Lehman A , Ahmed S , Mohajeri A , Yang GX, Berezuk AM, Mannar D , Cholak S, Tuttle KS, Bennett JT , Magno JA , Hannibal M , Kovacevic G, Kuburovic V, Lewis MES, Moldovan O, Nelson Z, Raskin S, Vandersteen AM, Roach JC, Subramaniam S, Patel MS
VCP variants cause Adams-Oliver syndrome with or without pulmonary hypertension.
Lehman A , Ahmed S , Mohajeri A , Berezuk AM, Mannar D , Cholak S, Tuttle KS, Bennett JT , Magno JA , Hannibal M , Kovacevic G, Kuburovic V, Lewis MES, Moldovan O, Nelson Z, Raskin S, Vandersteen AM, Roach JC, Subramaniam S, Patel MS
(2026) Genet Med , 28 , 102579 - 102579
PUBMED: 41979051
DOI: doi:10.1016/j.gim.2026.102579
ISSN: 1530-0366