EMD-72353

Single-particle
2.7 Å
EMD-72353
3D View Gallery
Deposition: 27/08/2025
Map released: 05/08/2026
Last modified: 23/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-72353

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9xzg summary report (pdf.gz) Map-9xzg FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of ALK in complex with CRBN/DDB1 and TRI-611

EMD-72353

Single-particle
2.7 Å
EMD-72353
3D View Gallery
Deposition: 27/08/2025
Map released: 05/08/2026
Last modified: 23/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Ternary complex of ALK with CRBN/DDB1 and TRI-611
Fitted models: 9xzg

Deposition Authors: Bart AG, Kamadurai HB
TRI-611, a selective, brain-penetrant molecular glue degrader of ALK.
Conery AR , La DS, Alekseyenko AA, Marcoux D, Bart AG, Harlow ML, Arsenault PR, Cantone NR , Casaubon RL, Constan A, Kamadurai HB, Medikonda AP, Nunes DE , Szeto H, Wigle TJ, Yu M, Zagulyaeva A, Zarate CM, Highfield L, Kondo N, Hata AN , Ngo K , Lee J, Gokhale PC , Germa C, Seyb KI, Trojer P, Palombella VJ
(2026) Nature
PUBMED: 42717093
DOI: doi:10.1038/s41586-026-10998-3
ISSN: 1476-4687
ASTM: NATUAS
Grant Support: