EMD-72339

Single-particle
3.2 Å
EMD-72339
3D View Gallery
Deposition: 26/08/2025
Map released: 14/10/2026
Last modified: 14/10/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-72339

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9xyj summary report (pdf.gz) Map-9xyj FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Human mitochondrial ClpP V62A variant

EMD-72339

Single-particle
3.2 Å
EMD-72339
3D View Gallery
Deposition: 26/08/2025
Map released: 14/10/2026
Last modified: 14/10/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Human mitochondrial ClpP V62A mutant
Fitted models: 9xyj

Deposition Authors: Uday AB, Zeytuni N, Goncalves M, Vahidi S
Allosteric inhibition of human mitochondrial ClpP by hijacking the dordaviprone (ONC201) binding site
Goncalves MM, Uday AB, Watson IDG, Chau AM, Kalhor-Monfared S, Wan B, Kiyota T, Currie SQW, Jitkova Y, Feng Y, Diamandas M, Ling D, Ma M, Mancini RS, Wang Z, Casas-Selves M, Joshi D, Mohammed M, Subramaniam R, Fernandes EL, Yan Y, Pomroy N, Hurren R, Gronda M, Velyvis A, Yudin AK, Reed MA, Prive G, Aman A, Isaac M, Marcellus R, Uehling D, Schimmer AD, Zeytuni N, Vahidi S
(2026) Nat Commun
DOI: doi:10.1038/s41467-026-78140-5
ISSN: 2041-1723