EMD-72221

Single-particle
2.33 Å
EMD-72221
3D View Gallery
Deposition: 20/08/2025
Map released: 14/01/2026
Last modified: 14/01/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-72221

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9q50 summary report (pdf.gz) Map-9q50 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

AK01 integrase inhibitor bound to Wild-type HIV-1 intasome

EMD-72221

Single-particle
2.33 Å
EMD-72221
3D View Gallery
Deposition: 20/08/2025
Map released: 14/01/2026
Last modified: 14/01/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: HIV-1 06TG.HT008, HIV type 1
Sample: integrase strand transfer inhibitor AK01 bound to HIV-1 wild-type intasome
Fitted models: 9q50

Deposition Authors: Jing T, Li M, Lyumkis D
Pi-pi stacking interactions with viral DNA contribute to the potency of naphthyridine-based HIV-1 integrase inhibitors.
Zhao XZ , Li M, Smith SJ, Karbasi A , Choudhuri I, Jing T, Lyumkis D , Craigie R, Burke Jr TR
(2025) Nar Mol Med , 2 , ugaf039 - ugaf039
PUBMED: 41426354
DOI: doi:10.1093/narmme/ugaf039
ISSN: 2976-856X