EMD-72086

Single-particle
3.15 Å
EMD-72086
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Deposition: 12/08/2025
Map released: 15/10/2025
Last modified: 05/11/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-72086
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9q03 summary report (pdf.gz) Map and 9q03 FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of ternary complex BCL6-CRBN-DDB1 with BCL6-760 (LDD, local refined)

EMD-72086

Single-particle
3.15 Å
EMD-72086
3D View Gallery
Deposition: 12/08/2025
Map released: 15/10/2025
Last modified: 05/11/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: ternary complex of BCL6-CRBN-DDB1 with an LDD BCL6-760
Fitted models: 9q03

Deposition Authors: Zhu J, Fang W, Pagarigan B
Discovery of Potent and Selective BCL6 Ligand-Directed Degrader (LDD), BCL6-760.
Shunatona HP, Holmberg Douglas N, Rhodes J, Thomas W, Da Silva D, Gamez J, Groza M, Christoforou A, Zhu J, Johnson S, Dodd D, Huang D, Griffin J, Miseo G, Whitefield B, Weiss D, Rader J, Kuzu E, Leisten J, Del Rosario J, Shi L, Matyskiela M, Chamberlain PP, Belmont P, Alexander M, Zapf CW, Groocock L, Mortensen DS
(2025) J Med Chem , 68 , 21502 - 21519
PUBMED: 41055242
DOI: doi:10.1021/acs.jmedchem.5c01645
ISSN: 0022-2623
ASTM: JMCMAR
Grant Support: