Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-72015

Single-particle
4.28 Å
EMD-72015
3D View Gallery
Deposition: 07/08/2025
Map released: 12/11/2025
Last modified: 12/11/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-72015
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
EMICSS annotations (xml)

Latent-state loperamide-mu opioid receptor-Gi GDPbS complex (rebound) - Locally refined map

EMD-72015

Single-particle
4.28 Å
EMD-72015
3D View Gallery
Deposition: 07/08/2025
Map released: 12/11/2025
Last modified: 12/11/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Loperamide-mu opioid receptor in complex with Gai-GDPbS, Gb1 and Gg2

Deposition Authors: Gati C, Khan S, Han GW

Ligand efficacy is driven by conformational control of nucleotide exchange at the mu opioid receptor.
Khan S, Han GW, Gati C
To Be Published