EMD-71744

Single-particle
2.3 Å
EMD-71744
3D View Gallery
Deposition: 18/07/2025
Map released: 20/08/2025
Last modified: 15/10/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-71744

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9pn0 summary report (pdf.gz) Map-9pn0 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Structure of HTTQ23-HAP40 complex bound to macrocycles HHD3, HD4 and HL2

EMD-71744

Single-particle
2.3 Å
EMD-71744
3D View Gallery
Deposition: 18/07/2025
Map released: 20/08/2025
Last modified: 15/10/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct
Sample: HTT Q23 - HAP40 complex with macrocycles HHD3, HD4 and HL2
Fitted models: 9pn0

Deposition Authors: Balakrishnan S, Deme J, Lea SM, Harding RJ
High-Affinity, Structure-Validated and Selective Macrocyclic Peptide Tools for Chemical Biology Studies of Huntingtin.
Wolf E, Fanti R, Ikenoue T, Deme JC, Balakrishnan S, Keith BA, Alteen MG, Chandrasekaran R, Yadav M, Bhajiawala R, Ackloo S, Feng J, Pouladi MA, Edwards AM, Wilson D, Lea SM, Suga H, Harding RJ
(2025) bioRxiv
PUBMED: 41030958
DOI: doi:10.1101/2025.08.06.668955
ISSN: 2692-8205