EMD-71743

Single-particle
2.1 Å
EMD-71743
3D View Gallery
Deposition: 18/07/2025
Map released: 20/08/2025
Last modified: 15/10/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-71743
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9pmw summary report (pdf.gz) Map and 9pmw FULL report (pdf.gz)
EMICSS annotations (xml)

Structure of HTTQ23-HAP40 complex bound to macrocycles HHL1, HD4 and HL2

EMD-71743

Single-particle
2.1 Å
EMD-71743
3D View Gallery
Deposition: 18/07/2025
Map released: 20/08/2025
Last modified: 15/10/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, synthetic construct
Sample: HTT Q23 - HAP40 complex with macrocycles HHL1, HD4 and HL2
Fitted models: 9pmw

Deposition Authors: Balakrishnan S, Deme J, Lea SM, Harding RJ
High-Affinity, Structure-Validated and Selective Macrocyclic Peptide Tools for Chemical Biology Studies of Huntingtin.
Wolf E, Fanti R, Ikenoue T, Deme JC, Balakrishnan S, Keith BA, Alteen MG, Chandrasekaran R, Yadav M, Bhajiawala R, Ackloo S, Feng J, Pouladi MA, Edwards AM, Wilson D, Lea SM, Suga H, Harding RJ
(2025) bioRxiv
PUBMED: 41030958
DOI: doi:10.1101/2025.08.06.668955
ISSN: 2692-8205