EMD-71719

Single-particle
2.74 Å
EMD-71719
3D View Gallery
Deposition: 15/07/2025
Map released: 30/07/2025
Last modified: 17/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-71719

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9plo summary report (pdf.gz) Map-9plo FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Structure of alpha2a adrenergic receptor in complex with Go heterotrimer, scFv16, and N-(5-methylnaphthalen-1-yl)pyridin-4-amine (compound 4905)

EMD-71719

Single-particle
2.74 Å
EMD-71719
3D View Gallery
Deposition: 15/07/2025
Map released: 30/07/2025
Last modified: 17/06/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Mus musculus
Sample: Alpha2a adrenergic receptor in complex with Go heterotrimer, scFv16, and compound 4905.
Fitted models: 9plo

Deposition Authors: Srinivasan K , Xu X , Mailhot O , Manglik A , Shoichet B
Toward a Random Background for Ligand Optimization.
Xu X , Mailhot O , Correy GJ, Huang XP, Braz J, Shi D, Srinivasan K , Zielinski K, Holota Y, Kuziv Y, Tsoutsouvas C, Levinzon N, Doruk YU, Rachman M, Diolaiti M, Stevens M, Liu F, Holland K, Hubner H, Wang J, Wu Y, Ashworth A, Makriyannis A, Zhang Y, Moroz Y, Gmeiner P, Abel R, Manglik A , Basbaum AI, Roth BL, Fraser JS, Shoichet BK
(2026) bioRxiv
PUBMED: 42182464
DOI: doi:10.64898/2026.05.10.724162
ISSN: 2692-8205
Grant Support: