Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-71502

Single-particle
6.93 Å
EMD-71502
3D View Gallery
Deposition: 27/06/2025
Map released: 10/09/2025
Last modified: 01/10/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-71502
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
EMICSS annotations (xml)

Structure of Synaptic Vesicle Protein 2A Bound to Levetiracetam and UCB1244283

EMD-71502

Single-particle
6.93 Å
EMD-71502
3D View Gallery
Deposition: 27/06/2025
Map released: 10/09/2025
Last modified: 01/10/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: SV2A bound to levetiracetam and UCB1244283

Deposition Authors: Mittal A , Martin MF , Ledecq M , Horanyi PS , Coleman JA
Mechanisms underlying allosteric modulation of antiseizure medication binding to synaptic vesicle protein 2A (SV2A).
Mittal A , Martin MF , Provins L, Hall A , Ledecq M , Wolff C, Gillard M, Horanyi PS , Coleman JA
(2025) PNAS , 122 , e2510239122 - e2510239122
PUBMED: 40892927
DOI: doi:10.1073/pnas.2510239122
ISSN: 1091-6490
ASTM: PNASA6
Grant Support: