EMD-71398
Cryo-EM structure of the PAC1sR-PACAP27-Gs complex
EMD-71398
Single-particle3.0 Å
Deposition: 24/06/2025Map released: 19/11/2025
Last modified: 03/12/2025
Sample Organism:
Homo sapiens,
Lama glama
Sample: Gs coupled Isoform S of Pituitary adenylate cyclase-activating polypeptide type I receptor complex with PACAP27 peptide
Fitted models: 9p94
Deposition Authors: Piper SJ
,
Sexton P,
Wootten D,
Wootten D
Sample: Gs coupled Isoform S of Pituitary adenylate cyclase-activating polypeptide type I receptor complex with PACAP27 peptide
Fitted models: 9p94
Deposition Authors: Piper SJ
,
Sexton P,
Wootten D,
Wootten D
Structural basis of modified ligand selectivity from N-terminal PAC1R alternative splicing.
Lu JJ,
Deganutti G ,
Li M,
Humphrys LJ ,
Li Y,
Nettleton TJ ,
Venugopal H,
Julita V,
Christopoulos G,
Reynolds CA ,
Sexton PM ,
Wootten D,
Zhao P,
Piper SJ
(2025) PNAS , 122 , e2521157122 - e2521157122
,
Li M,
Humphrys LJ ,
Li Y,
Nettleton TJ ,
Venugopal H,
Julita V,
Christopoulos G,
Reynolds CA ,
Sexton PM ,
Wootten D,
Zhao P,
Piper SJ
(2025) PNAS , 122 , e2521157122 - e2521157122
Grant Support:
- National Health and Medical Research Council (NHMRC, Australia): 1155302 (Australia)
- National Health and Medical Research Council (NHMRC, Australia): 1150083 (Australia)
- National Health and Medical Research Council (NHMRC, Australia): 1154434 (Australia)
- National Health and Medical Research Council (NHMRC, Australia): 2025694 (Australia)
- National Health and Medical Research Council (NHMRC, Australia): 2026300 (Australia)
- Australian Research Council (ARC): 230102776 (Australia)