EMD-71397

Single-particle
3.2 Å
EMD-71397
3D View Gallery
Deposition: 24/06/2025
Map released: 19/11/2025
Last modified: 03/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-71397
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9p93 summary report (pdf.gz) Map and 9p93 FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of the PAC1sR-VIP-Gs complex

EMD-71397

Single-particle
3.2 Å
EMD-71397
3D View Gallery
Deposition: 24/06/2025
Map released: 19/11/2025
Last modified: 03/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Lama glama
Sample: Gs coupled Isoform S of Pituitary adenylate cyclase-activating polypeptide type I receptor complex with VIP peptide
Fitted models: 9p93

Deposition Authors: Piper SJ , Lu J, Sexton P, Wootten D
Structural basis of modified ligand selectivity from N-terminal PAC1R alternative splicing.
Lu JJ, Deganutti G , Li M, Humphrys LJ , Li Y, Nettleton TJ , Venugopal H, Julita V, Christopoulos G, Reynolds CA , Sexton PM , Wootten D, Zhao P, Piper SJ
(2025) PNAS , 122 , e2521157122 - e2521157122
PUBMED: 41264251
DOI: doi:10.1073/pnas.2521157122
ISSN: 1091-6490
ASTM: PNASA6