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EMD-71039
Subtomogram average of Munc13-1 C1-C2B-MUN-C2C F1176N/I1215N mutant 2D crystal between lipid bilayers
EMD-71039
Subtomogram averaging36.0 Å
Deposition: 04/06/2025Map released: 20/08/2025
Last modified: 20/08/2025
Sample Organism:
Rattus norvegicus
Sample: 2D crystal of Munc13-1 C1-C2B-MUN-C2C F1176N/I1215N mutant between negatively charged lipid bilayers
Deposition Authors: Grushin K
,
Radhakrishnan A
Sample: 2D crystal of Munc13-1 C1-C2B-MUN-C2C F1176N/I1215N mutant between negatively charged lipid bilayers
Deposition Authors: Grushin K
,
Radhakrishnan A
Two successive oligomeric Munc13 assemblies scaffold vesicle docking and SNARE assembly to support neurotransmitter release.
Bera M ,
Grushin K ,
Kalyana Sundaram RV ,
Hinzen JS,
Chen J,
Chatterjee A,
Radhakrishnan A ,
Lee S,
Padmanarayana M,
Coleman J,
Pincet F ,
Rothman JE,
Dittman JS
(2025) Nat Commun , 16 , 7222 - 7222
,
Grushin K ,
Kalyana Sundaram RV ,
Hinzen JS,
Chen J,
Chatterjee A,
Radhakrishnan A ,
Lee S,
Padmanarayana M,
Coleman J,
Pincet F ,
Rothman JE,
Dittman JS
(2025) Nat Commun , 16 , 7222 - 7222
Grant Support:
- National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK): NIH DK 027044 (United States)
- National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS): NIH NS 130894 (United States)
- National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS): NIH NS 116747 (United States)