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EMD-70869
DDB1-CRBN with ikaros(ZF2) with SB-405483, and DEG-47: Focused map submission
EMD-70869
Single-particle3.17 Å
Deposition: 28/05/2025Map released: 19/11/2025
Last modified: 24/12/2025
Sample Organism:
Homo sapiens
Sample: DDB1(BPB deleted)-CRBN complex with ikaros ZF2-3, SB-405483, and DEG-47 was incubated for 30 minutes and then plunge frozen over 1.2/1.3 UltrAufoil
Deposition Authors: Rizvi Z
,
Lander GC
Sample: DDB1(BPB deleted)-CRBN complex with ikaros ZF2-3, SB-405483, and DEG-47 was incubated for 30 minutes and then plunge frozen over 1.2/1.3 UltrAufoil
Deposition Authors: Rizvi Z
,
Lander GC
Identification of a cryptic allosteric site on the E3 ligase adapter protein cereblon
Rizvi Z ,
Dippon VN,
Choudhry AE,
Chung CW,
Alkuraya AF,
Xu W,
Tao XB,
Jurewicz AJ,
Schneck JL,
Chen W,
Curnutt NM,
Kabir F,
Chan KH,
Queisser MA,
Musetti C,
Dai H,
Benowitz AB,
Woo CM,
Lander GC
(2025) Nature
,
Dippon VN,
Choudhry AE,
Chung CW,
Alkuraya AF,
Xu W,
Tao XB,
Jurewicz AJ,
Schneck JL,
Chen W,
Curnutt NM,
Kabir F,
Chan KH,
Queisser MA,
Musetti C,
Dai H,
Benowitz AB,
Woo CM,
Lander GC
(2025) Nature
Grant Support: