EMD-70867

Single-particle
2.69 Å
EMD-70867
3D View Gallery
Deposition: 28/05/2025
Map released: 03/12/2025
Last modified: 25/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-70867

Archive Files (Depositor)

Primary 3D volume (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9ouk summary report (pdf.gz) Map-9ouk FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

DDB1-CRBN with Ikaros(ZF2) and DEG-47: composite map and model submission

EMD-70867

Single-particle
2.69 Å
EMD-70867
3D View Gallery
Deposition: 28/05/2025
Map released: 03/12/2025
Last modified: 25/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: DDB1(BPB deleted)-CRBN complex with ikaros ZF2-3 and DEG-47 was incubauted for 30 minutes and then plunge frozen over 1.2/1.3 UltrAufoil
Fitted models: 9ouk

Deposition Authors: Rizvi Z , Lander GC
Identification of an allosteric site on the E3 ligase adapter cereblon.
Dippon VN , Rizvi Z , Choudhry AE, Chung CW , Alkuraya IF, Xu W , Tao XB , Jurewicz AJ, Schneck JL , Chen W, Curnutt NM , Kabir F, Chan KH , Queisser MA , Musetti C, Dai H, Lander GC , Benowitz AB , Woo CM
(2026) Nature , 651 , 482 - 490
PUBMED: 41565821
DOI: doi:10.1038/s41586-025-09994-w
ISSN: 1476-4687
ASTM: NATUAS