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EMD-70862

Composite map
Single-particle
3.0 Å
EMD-70862
3D View Gallery
Deposition: 27/05/2025
Map released: 19/11/2025
Last modified: 24/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-70862
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9oty summary report (pdf.gz) Map and 9oty FULL report (pdf.gz)
EMICSS annotations (xml)

DDB1-CRBN with CK1 alpha, SB-405483, and DEG-47: composite map and model submission

EMD-70862

Composite map
Single-particle
3.0 Å
EMD-70862
3D View Gallery
Deposition: 27/05/2025
Map released: 19/11/2025
Last modified: 24/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: DDB1(BPB deleted)-CRBN complex with Casein kinase 1 alpha, SB-405483, and DEG-47
Fitted models: 9oty

Deposition Authors: Rizvi Z, Lander GC
Identification of a cryptic allosteric site on the E3 ligase adapter protein cereblon
Rizvi Z, Dippon VN, Choudhry AE, Chung CW, Alkuraya AF, Xu W, Tao XB, Jurewicz AJ, Schneck JL, Chen W, Curnutt NM, Kabir F, Chan KH, Queisser MA, Musetti C, Dai H, Benowitz AB, Woo CM, Lander GC
(2025) Nature
DOI: doi:10.1038/s41586-025-09994-w
ISSN: 1476-4687
ASTM: NATUAS