EMD-70719

Single-particle
3.2 Å
EMD-70719
3D View Gallery
Deposition: 19/05/2025
Map released: 29/07/2026
Last modified: 29/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-70719

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9opj summary report (pdf.gz) Map-9opj FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

cryoEM structure of IRAK4:KT-474:CRBN-DDB1 ternary complex

EMD-70719

Single-particle
3.2 Å
EMD-70719
3D View Gallery
Deposition: 19/05/2025
Map released: 29/07/2026
Last modified: 29/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: IRAK4:KT-474:CRBN-DDB1 ternary complex
Fitted models: 9opj

Deposition Authors: Fei X, Ramanathan A, Diagle C, Ford M, Campbell V, Zheng X, Li H, Sintchak M, Kamadurai H, Miller R, Kazmirski S, Huang X, Weiss M, Manolfi N, Zhu X
Structural basis for selective and potent degradation of IRAK4 by KT-474.
Fei X, Ramanathan A, Daigle CA, Ford M, Campbell V, Zheng X, Sintchak M, Li H, Kamadurai H, Miller R, Kazmirski S, Huang X, Weiss MM, Mainolfi N, Zhu X
(2026) Nat Commun
PUBMED: 42336816
DOI: doi:10.1038/s41467-026-74105-w
ISSN: 2041-1723
Grant Support: