Single particle reconstruction
6.5Å resolution

Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11 heavy chain and FAB H11 light chain

Map released:
Last modified:
Overview of EMD-7066
Source organism: Homo sapiens [9606]
Fitted atomic model: 6b7z
Related EM entries by publication: EMD-7041, EMD-7062, EMD-7065, EMD-7090, EMD-7091, EMD-7092, EMD-7093
Primary publication:
Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Zhang Z, Liang WG, Bailey LJ, Tan YZ, Wei H, Wang A, Farcasanu M, Woods VA, McCord LA, Lee D, Shang W, Deprez-Poulain R, Deprez B, Liu DR, Koide A, Koide S, Kossiakoff AA, Li S, Carragher B, Potter CS, Tang WJ
Elife 7 - (2018)
PMID: 29596046

Function and Biology Details

Sample name: Insulin degrading enzyme
Proteins: Insulin degrading enzyme, Insulin-degrading enzyme, FAB H11 heavy chain, FAB H11 light chain

Experimental Information Details

Resolution: 6.5Å
Resolution method: FSC 0.143 CUT-OFF
Reconstruction software: RELION
Detector: GATAN K2 (4k x 4k)