EMD-7065
Cryo-EM structure of human insulin degrading enzyme in complex with insulin
EMD-7065
Single-particle6.5 Å
Deposition: 05/10/2017Map released: 08/11/2017
Last modified: 13/03/2024
Sample Organism:
Homo sapiens
Sample: Insulin degrading enzyme
Fitted models: 6b7y
Deposition Authors: Zhang Z, Liang WG, Bailey LJ, Tan YZ
,
Wei H,
Kossiakoff AA,
Carragher B ,
Potter SC,
Tang WJ
Sample: Insulin degrading enzyme
Fitted models: 6b7y
Deposition Authors: Zhang Z, Liang WG, Bailey LJ, Tan YZ
,
Wei H,
Kossiakoff AA,
Carragher B ,
Potter SC,
Tang WJ
Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Zhang Z,
Liang WG,
Bailey LJ,
Tan YZ ,
Wei H,
Wang A,
Farcasanu M,
Woods VA,
McCord LA,
Lee D ,
Shang W,
Deprez-Poulain R ,
Deprez B,
Liu DR,
Koide A,
Koide S,
Kossiakoff AA,
Li S,
Carragher B ,
Potter CS ,
Tang WJ
(2018) eLife , 7
,
Wei H,
Wang A,
Farcasanu M,
Woods VA,
McCord LA,
Lee D ,
Shang W,
Deprez-Poulain R ,
Deprez B,
Liu DR,
Koide A,
Koide S,
Kossiakoff AA,
Li S,
Carragher B ,
Potter CS ,
Tang WJ
(2018) eLife , 7
Grant Support:
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): GM103310 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): GM81539 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): GM121964 (United States)
- Simons Foundation: 349247 (United States)