EMD-70618

Single-particle
2.95 Å
EMD-70618
3D View Gallery
Deposition: 14/05/2025
Map released: 22/10/2025
Last modified: 12/08/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-70618

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9omv summary report (pdf.gz) Map-9omv FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of the C. neoformans lipid flippase Apt1-Cdc50 bound with butyrolactol A in the E2P state

EMD-70618

Single-particle
2.95 Å
EMD-70618
3D View Gallery
Deposition: 14/05/2025
Map released: 22/10/2025
Last modified: 12/08/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Cryptococcus neoformans var. grubii H99
Sample: Apt1-Cdc50 heterodimer bound with butyrolactol A
Fitted models: 9omv

Deposition Authors: Duan HD, Li H
Butyrolactol A enhances caspofungin efficacy via flippase inhibition in drug-resistant fungi.
Chen X, Duan HD, Hoy MJ, Koteva K, Spitzer M, Guitor AK , Puumala E, Fiebig AA, Hu G, Yiu B, Chou S, Bian Z, Choi Y, Guo ABY, Wang W, Sun S, Robbins N, Averette AF, Cook MA, Truant R, MacNeil LT, Brown ED, Kronstad JW, Coombes BK, Cowen LE, Heitman J, Li H, Wright GD
(2026) Cell , 189 , 620
PUBMED: 41478284
DOI: doi:10.1016/j.cell.2025.11.036
ISSN: 1097-4172