EMD-70462

Single-particle
2.49 Å
EMD-70462
3D View Gallery
Deposition: 30/04/2025
Map released: 26/11/2025
Last modified: 22/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-70462
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9ogd summary report (pdf.gz) Map and 9ogd FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of human exportin-1 conjugated with selinexor and bound to human ASB8(R197A)-ELOB/C

EMD-70462

Single-particle
2.49 Å
EMD-70462
3D View Gallery
Deposition: 30/04/2025
Map released: 26/11/2025
Last modified: 22/07/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Ternary complex of full-length human XPO1 conjugated to KPT-185 and bound to ASB8(R197A)-ELOB/C
Fitted models: 9ogd

Deposition Authors: Wing CE , Fung HYJ , Chook YM
SINE compounds activate exportin 1 degradation through an allosteric mechanism.
Wing CE , Fung HYJ , Kwanten B , Cagatay T , Niesman AB , Jacquemyn M , Gharghabi M , Permentier B , Shakya B, Nandi R, Ready JM, Kashyap T, Shacham S, Landesman Y, Lapalombella R , Daelemans D , Chook YM
(2025) Nat Chem Biol , 21 , 2002 - 2013
PUBMED: 41286136
DOI: doi:10.1038/s41589-025-02058-0
ISSN: 1552-4469