EMD-70460

Single-particle
3.25 Å
EMD-70460
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Deposition: 30/04/2025
Map released: 26/11/2025
Last modified: 03/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-70460
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9ogb summary report (pdf.gz) Map and 9ogb FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of human exportin-1 conjugated with selinexor and bound to yeast RAN-GTP and human ASB8-ELOB/C

EMD-70460

Single-particle
3.25 Å
EMD-70460
3D View Gallery
Deposition: 30/04/2025
Map released: 26/11/2025
Last modified: 03/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Saccharomyces cerevisiae
Sample: Quinary complex of full-length human XPO1 conjugated to selinexor and bound to RAN<sup>GTP</sup> and ASB8-ELOB/C
Fitted models: 9ogb

Deposition Authors: Wing CE, Fung HYJ, Chook YM
SINE compounds activate exportin-1 degradation via an allosteric mechanism.
Wing CE, Fung HYJ, Kwanten B, Cagatay T, Niesman AB, Jacquemyn M, Gharghabi M, Permentier B, Shakya B, Nandi R, Ready JM, Kashyap T, Shacham S, Landesman Y, Lapalombella R, Daelemans D, Chook YM
(2025) bioRxiv
PUBMED: 39416201
DOI: doi:10.1101/2024.10.07.617049
ISSN: 2692-8205