EMD-70460
Cryo-EM structure of human exportin-1 conjugated with selinexor and bound to yeast RAN-GTP and human ASB8-ELOB/C
EMD-70460
Single-particle3.25 Å
Deposition: 30/04/2025Map released: 26/11/2025
Last modified: 03/12/2025
Sample Organism:
Homo sapiens,
Saccharomyces cerevisiae
Sample: Quinary complex of full-length human XPO1 conjugated to selinexor and bound to RAN<sup>GTP</sup> and ASB8-ELOB/C
Fitted models: 9ogb
Deposition Authors: Wing CE
,
Fung HYJ ,
Chook YM
Sample: Quinary complex of full-length human XPO1 conjugated to selinexor and bound to RAN<sup>GTP</sup> and ASB8-ELOB/C
Fitted models: 9ogb
Deposition Authors: Wing CE
,
Fung HYJ ,
Chook YM
SINE compounds activate exportin-1 degradation via an allosteric mechanism.
Wing CE ,
Fung HYJ ,
Kwanten B ,
Cagatay T ,
Niesman AB ,
Jacquemyn M ,
Gharghabi M ,
Permentier B ,
Shakya B,
Nandi R,
Ready JM,
Kashyap T,
Shacham S,
Landesman Y,
Lapalombella R ,
Daelemans D ,
Chook YM
(2025) bioRxiv
,
Fung HYJ ,
Kwanten B ,
Cagatay T ,
Niesman AB ,
Jacquemyn M ,
Gharghabi M ,
Permentier B ,
Shakya B,
Nandi R,
Ready JM,
Kashyap T,
Shacham S,
Landesman Y,
Lapalombella R ,
Daelemans D ,
Chook YM
(2025) bioRxiv
Grant Support:
- Cancer Prevention and Research Institute of Texas (CPRIT): RP220582 (United States)
- Cancer Prevention and Research Institute of Texas (CPRIT): RP180410 (United States)
- Cancer Prevention and Research Institute of Texas (CPRIT): 150053 (United States)
- Cancer Prevention and Research Institute of Texas (CPRIT): RP170170 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): R35GM144137 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): T32GM131963 (United States)
- Welch Foundation: I-1532 (United States)