Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-70459

Single-particle
3.37 Å
EMD-70459
3D View Gallery
Deposition: 30/04/2025
Map released: 26/11/2025
Last modified: 03/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-70459
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9oga summary report (pdf.gz) Map and 9oga FULL report (pdf.gz)
EMICSS annotations (xml)

Cryo-EM structure of human full-length XPO1 conjugated with selinexor

EMD-70459

Single-particle
3.37 Å
EMD-70459
3D View Gallery
Deposition: 30/04/2025
Map released: 26/11/2025
Last modified: 03/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Human wildtype full-length exportin-1 (XPO1) covalently bound to selinexor
Fitted models: 9oga

Deposition Authors: Wing CE , Fung HYJ , Chook YM
SINE compounds activate exportin-1 degradation via an allosteric mechanism.
Wing CE , Fung HYJ , Kwanten B , Cagatay T , Niesman AB , Jacquemyn M , Gharghabi M , Permentier B , Shakya B, Nandi R, Ready JM, Kashyap T, Shacham S, Landesman Y, Lapalombella R , Daelemans D , Chook YM
(2025) bioRxiv
PUBMED: 39416201
DOI: doi:10.1101/2024.10.07.617049
ISSN: 2692-8205