Single particle reconstruction
3.62Å resolution

TRPML3/ML-SA1 complex at pH 7.4

Map released:
Last modified:
Overview of EMD-7019
Source organism: Homo sapiens [9606]
Fitted atomic model: 6ayf
Related EM entry by publication: EMD-7018, EMD-7020
Primary publication:
Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states.
Zhou X, Li M, Su D, Jia Q, Li H, Li X, Yang J
Nat. Struct. Mol. Biol. 24 1146-1154 (2017)
PMID: 29106414

Function and Biology Details

Sample name: TRPML3 channel bound with a agonist ML-SA1
Ligand: 2-acetamido-2-deoxy-beta-D-glucopyranose
Proteins: TRPML3 channel bound with a agonist ML-SA1, Mucolipin-3

Experimental Information Details

Resolution: 3.62Å
Resolution method: FSC 0.143 CUT-OFF
Applied symmetry: C4
Reconstruction software: THUNDER
Detector: GATAN K2 SUMMIT (4k x 4k)