EMD-7012

Single-particle
35.0 Å
EMD-7012
3D View Gallery
Deposition: 04/09/2017
Map released: 01/11/2017
Last modified: 13/03/2024
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-7012

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-6avr summary report (pdf.gz) Map-6avr FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

Human alpha-V beta-3 Integrin (intermediate conformation) in complex with the therapeutic antibody LM609

EMD-7012

Single-particle
35.0 Å
EMD-7012
3D View Gallery
Deposition: 04/09/2017
Map released: 01/11/2017
Last modified: 13/03/2024
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Mus musculus
Sample: Quaternary complex of human alpha-V beta-3 integrin with the Fab LM609
Fitted models: 6avr

Deposition Authors: Borst AJ , James ZN
The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human alpha V beta 3 Integrin via Steric Hindrance.
Borst AJ , James ZM, Zagotta WN, Ginsberg M, Rey FA , DiMaio F, Backovic M , Veesler D
(2017) Structure , 25 , 1732 - 1739.e5
PUBMED: 29033288
DOI: doi:10.1016/j.str.2017.09.007
ISSN: 1878-4186
ASTM: STRUE6