EMD-70093

Helical reconstruction
2.59 Å
EMD-70093
3D View Gallery
Deposition: 08/04/2025
Map released: 23/04/2025
Last modified: 23/04/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-70093

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9o4b summary report (pdf.gz) Map-9o4b FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of in-vitro alpha-synuclein fibril bound with Exemplar-6 PET-radioligand

EMD-70093

Helical reconstruction
2.59 Å
EMD-70093
3D View Gallery
Deposition: 08/04/2025
Map released: 23/04/2025
Last modified: 23/04/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: alpha-synuclein fibril with Exemplar-6 PET-radioligand
Fitted models: 9o4b

Deposition Authors: Sanchez JC , Perez RM, Borcik CG , Guarino DS, Dhavala DD, Baumgardt JK, Shaffer KD, Kotzbauer PT, Mach RH, Rienstra CM , Petersson EJ , Wright ER

Complementary Structural and Chemical Biology Methods Reveal the Basis for Selective Radioligand Binding to Alpha-Synuclein in MSA Tissue
Sanchez JC , Perez RM, Borcik CG , Guarino DS, Dhavala DD, Baumgardt JK, Shaffer KD, Kotzbauer PT, Mach RH, Rienstra CM , Petersson EJ , Wright ER
To Be Published