EMD-70077
Plasmodium falciparum 20S proteasome bound to inhibitor 159
EMD-70077
Single-particle2.79 Å
Deposition: 07/04/2025Map released: 12/11/2025
Last modified: 26/11/2025
Sample Organism:
Plasmodium falciparum 3D7
Sample: Plasmodium falciparum 20S proteasome bound with inhibitor 159
Fitted models: 9o3e
Deposition Authors: Han Y, Deng X, Ray S
,
Phillips M,
Phillips M
Sample: Plasmodium falciparum 20S proteasome bound with inhibitor 159
Fitted models: 9o3e
Deposition Authors: Han Y, Deng X, Ray S
,
Phillips M,
Phillips M
Optimization of Species-Selective Reversible Proteasome Inhibitors for the Treatment of Malaria.
Gahalawat S,
Ray S ,
Zhang X,
Deng X,
Han Y,
Chen Z,
Lawong A,
Shackleford DM,
Katneni K,
Chen G,
Li P,
Ng A,
Zhong L,
Hu M,
McInerney M ,
Wang W,
Saunders J,
Collins D,
Jayaseelan J,
Noack CL,
C Maity B,
De N,
Laleu B ,
Campbell SF,
Phillips MA ,
Charman SA ,
Ready JM
(2025) J Med Chem , 68 , 23485 - 23520
,
Zhang X,
Deng X,
Han Y,
Chen Z,
Lawong A,
Shackleford DM,
Katneni K,
Chen G,
Li P,
Ng A,
Zhong L,
Hu M,
McInerney M ,
Wang W,
Saunders J,
Collins D,
Jayaseelan J,
Noack CL,
C Maity B,
De N,
Laleu B ,
Campbell SF,
Phillips MA ,
Charman SA ,
Ready JM
(2025) J Med Chem , 68 , 23485 - 23520
Grant Support:
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): R01AI103947 (United States)
- National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID): R01AI155784 (United States)
- National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS): GM007062 (United States)
- Cancer Prevention and Research Institute of Texas (CPRIT): RP220582 (United States)