EMD-70022
BG505 SOSIP in complex with 007 bNAb IgG1 - trimer-dimer class
EMD-70022
Single-particle4.2 Å
Deposition: 04/04/2025Map released: 01/10/2025
Last modified: 01/10/2025
Sample Organism:
Homo sapiens,
Human immunodeficiency virus 1
Sample: HIV-1 BG505 SOSIP trimer bound by three 007 bNAb IgG1 molecules
Fitted models: 9o2u
Deposition Authors: DeLaitsch AT, Bjorkman PJ
Sample: HIV-1 BG505 SOSIP trimer bound by three 007 bNAb IgG1 molecules
Fitted models: 9o2u
Deposition Authors: DeLaitsch AT, Bjorkman PJ
Identification of a broad and potent V3 glycan site bNAb targeting an N332 gp120 glycan-independent epitope.
Gieselmann L,
DeLaitsch AT,
Rohde M,
Radford C,
Worczinski J,
Momot A,
Ahmadov E,
Burger JA,
Havenar-Daughton C,
Deshpande S,
Giovannoni F,
Corti D,
Kreer C 
,
Ercanoglu MS,
Schommers P,
Georgiev IS,
West AP,
Knufer J,
Stumpf R,
Kroidl A,
Geldmacher C,
Maganga L,
William W,
Ntinginya NE,
Hoelscher M,
Yang Z,
Wei Q,
Renfrow M,
Green TJ,
Novak J,
van Gils MJ ,
Gristick HB ,
Gruell H ,
Bloom JD ,
Seaman MS,
Bjorkman PJ,
Klein F
(2025) bioRxiv
,
Ercanoglu MS,
Schommers P,
Georgiev IS,
West AP,
Knufer J,
Stumpf R,
Kroidl A,
Geldmacher C,
Maganga L,
William W,
Ntinginya NE,
Hoelscher M,
Yang Z,
Wei Q,
Renfrow M,
Green TJ,
Novak J,
van Gils MJ ,
Gristick HB ,
Gruell H ,
Bloom JD ,
Seaman MS,
Bjorkman PJ,
Klein F
(2025) bioRxiv
Grant Support:
- Bill & Melinda Gates Foundation: INV-002143 (United States)