EMD-6915

Single-particle
3.95 Å
EMD-6915
3D View Gallery
Deposition: 23/02/2018
Map released: 21/03/2018
Last modified: 29/01/2020
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-6915

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-5zya summary report (pdf.gz) Map-5zya FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

SF3b spliceosomal complex bound to E7107

EMD-6915

Single-particle
3.95 Å
EMD-6915
3D View Gallery
Deposition: 23/02/2018
Map released: 21/03/2018
Last modified: 29/01/2020
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: SF3b Sub-complex
Fitted models: 5zya

Deposition Authors: Finci LI, Larsen NA
The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action.
Finci LI, Zhang X , Huang X , Zhou Q, Tsai J, Teng T, Agrawal A, Chan B , Irwin S, Karr C, Cook A, Zhu P, Reynolds D, Smith PG, Fekkes P, Buonamici S, Larsen NA
(2018) Genes Dev. , 32 , 309 - 320
PUBMED: 29491137
DOI: doi:10.1101/gad.311043.117
ISSN: 1549-5477
ASTM: GEDEEP
Grant Support: