EMD-66358

Single-particle
4.4 Å
EMD-66358
3D View Gallery
Deposition: 26/09/2025
Map released: 11/02/2026
Last modified: 08/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-66358

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9wxv summary report (pdf.gz) Map-9wxv FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of TMEM63A-digitonin-cholesterol

EMD-66358

Single-particle
4.4 Å
EMD-66358
3D View Gallery
Deposition: 26/09/2025
Map released: 11/02/2026
Last modified: 08/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: TMEM63A with cholesterol
Fitted models: 9wxv

Deposition Authors: Lin Y , Zhou Z , Han Y , Cheng D , Wang H, Ju L, Zhang Y , Cox DC, Corry B
TMEM63 proteins act as mechanically activated cholesterol modulated lipid scramblases contributing to membrane mechano-resilience.
Lin Y , Zhou Z , Han Y , Cheng D , Wang HJ, Ju LA , Zhang Y , Cox CD , Corry B
(2026) Nat Commun , 17
PUBMED: 41617699
DOI: doi:10.1038/s41467-026-68919-x
ISSN: 2041-1723