EMD-65225
Cryo-EM Structure of Human GPR158 Bound to Nanobody Nb20
EMD-65225
Single-particle3.47 Å
Deposition: 02/07/2025Map released: 31/12/2025
Last modified: 18/02/2026
Sample Organism:
Homo sapiens,
Lama glama
Sample: GPR158 complexed with Nb20
Fitted models: 9vor
Deposition Authors: Laboute T
,
Zucca S ,
Sial M,
Sharma M ,
Brunori G,
Singh S ,
Singh A,
Martemyanov K
Sample: GPR158 complexed with Nb20
Fitted models: 9vor
Deposition Authors: Laboute T
,
Zucca S ,
Sial M,
Sharma M ,
Brunori G,
Singh S ,
Singh A,
Martemyanov K
Targeting mGlyR with nanobodies for depression.
Laboute T ,
Zucca S ,
Sial OK,
Sharma M ,
Brunori G,
Singh S ,
Nageswar KV,
Peng H ,
Rader C ,
Becker JA ,
Le Merrer J ,
Singh AK ,
Martemyanov KA
(2026) Nat Commun , 17 , 831 - 831
,
Zucca S ,
Sial OK,
Sharma M ,
Brunori G,
Singh S ,
Nageswar KV,
Peng H ,
Rader C ,
Becker JA ,
Le Merrer J ,
Singh AK ,
Martemyanov KA
(2026) Nat Commun , 17 , 831 - 831
Grant Support:
- National Institutes of Health/National Eye Institute (NIH/NEI): MH105482 (United States)
- National Institutes of Health/National Eye Institute (NIH/NEI): EY034339 (United States)
- Indian Council of Medical Research: Neuro/2022-NCD-I (India)
- Department of Biotechnology (DBT, India): Neuro/2022-NCD-I (India)