EMD-64791

Single-particle
2.85 Å
EMD-64791
3D View Gallery
Deposition: 26/05/2025
Map released: 08/04/2026
Last modified: 08/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-64791

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9v5p summary report (pdf.gz) Map-9v5p FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

CryoEM structure of human DNMT1 (aa 698-1616) in complex with hemimethylated dsDNA and inhibitor DMT207

EMD-64791

Single-particle
2.85 Å
EMD-64791
3D View Gallery
Deposition: 26/05/2025
Map released: 08/04/2026
Last modified: 08/04/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: human DNMT1 in complex with hemimethylated dsDNA and inhibitor DMT207
Fitted models: 9v5p

Deposition Authors: Li Z
Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating beta-Thalassemia.
Shen Y, Wei J, Tang S, Wu D, Zong L, Ma S, Xiong Q, Gong R, Xu S, Peng C, Feng Q, Liu S, Liu Q, Ye Y, Zhao Q , Luo C, Huang P, Li Z, Kong X, Lan X
(2026) Adv Sci , 13 , e13469 - e13469
PUBMED: 41347631
DOI: doi:10.1002/advs.202513469
ISSN: 2198-3844