EMD-64750

Single-particle
2.77 Å
EMD-64750
3D View Gallery
Deposition: 21/05/2025
Map released: 18/03/2026
Last modified: 30/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-64750

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9v36 summary report (pdf.gz) Map-9v36 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

CryoEM structure of human DNMT1 (aa 698-1616) bound to hemimethylated dsDNA and Inhibitor DMI26

EMD-64750

Single-particle
2.77 Å
EMD-64750
3D View Gallery
Deposition: 21/05/2025
Map released: 18/03/2026
Last modified: 30/09/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: human DNMT1 bound to hemimethylated dsDNA and DMI26
Fitted models: 9v36

Deposition Authors: Li Z
Structure-guided design of 7-azaindole DNMT1 inhibitors active against hypomethylating agent-resistant acute myeloid leukemia.
Tang S, Zong L, Ma S, Shang Y, Wei J, Liu J, Cui Y, Guo H, Zou K, Wang K, Li H, Ye F, Huang J, Luo C, Li Z, Baylin SB , Kong X
(2026) PNAS , 123 , e2532472123 - e2532472123
PUBMED: 41955111
DOI: doi:10.1073/pnas.2532472123
ISSN: 1091-6490
ASTM: PNASA6