EMD-63614
Structure-based discovery of potent agonists of the orphan receptor GPR139
EMD-63614
Single-particle3.2 Å
Deposition: 03/03/2025Map released: 21/01/2026
Last modified: 21/01/2026
Sample Organism:
Homo sapiens
Sample: GPR139_Gs/q
Fitted models: 9m42
Deposition Authors: Cabezadevaca I, Trapkov B
,
Shen L,
Pezeshki M ,
Zhang XH,
Liu Z,
Hauser AS ,
Carlsson J
Sample: GPR139_Gs/q
Fitted models: 9m42
Deposition Authors: Cabezadevaca I, Trapkov B
,
Shen L,
Pezeshki M ,
Zhang XH,
Liu Z,
Hauser AS ,
Carlsson J
Ultra-large virtual screening unveils potent agonists of the neuromodulatory orphan receptor GPR139.
Cabeza de Vaca I ,
Trapkov B ,
Shen L,
Vo DD,
Zhang X ,
Yang Y,
Pezeshki M ,
Zhang X ,
Ballgren F,
Saleh A,
Tarnovskiy AV,
Radchenko DS ,
Moroz YS ,
Brauner-Osborne H,
Svenningsson P ,
Kihlberg J ,
Liu ZJ ,
Hauser AS ,
Carlsson J
(2025) Nat Commun , 17 , 129 - 129
,
Trapkov B ,
Shen L,
Vo DD,
Zhang X ,
Yang Y,
Pezeshki M ,
Zhang X ,
Ballgren F,
Saleh A,
Tarnovskiy AV,
Radchenko DS ,
Moroz YS ,
Brauner-Osborne H,
Svenningsson P ,
Kihlberg J ,
Liu ZJ ,
Hauser AS ,
Carlsson J
(2025) Nat Commun , 17 , 129 - 129
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