EMD-63614

Single-particle
3.2 Å
EMD-63614
3D View Gallery
Deposition: 03/03/2025
Map released: 21/01/2026
Last modified: 21/01/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-63614

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9m42 summary report (pdf.gz) Map-9m42 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Structure-based discovery of potent agonists of the orphan receptor GPR139

EMD-63614

Single-particle
3.2 Å
EMD-63614
3D View Gallery
Deposition: 03/03/2025
Map released: 21/01/2026
Last modified: 21/01/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: GPR139_Gs/q
Fitted models: 9m42

Deposition Authors: Cabezadevaca I, Trapkov B , Shen L, Pezeshki M , Zhang XH, Liu Z, Hauser AS , Carlsson J
Ultra-large virtual screening unveils potent agonists of the neuromodulatory orphan receptor GPR139.
Cabeza de Vaca I , Trapkov B , Shen L, Vo DD, Zhang X , Yang Y, Pezeshki M , Zhang X , Ballgren F, Saleh A, Tarnovskiy AV, Radchenko DS , Moroz YS , Brauner-Osborne H, Svenningsson P , Kihlberg J , Liu ZJ , Hauser AS , Carlsson J
(2025) Nat Commun , 17 , 129 - 129
PUBMED: 41365886
DOI: doi:10.1038/s41467-025-66845-y
ISSN: 2041-1723
Grant Support: