EMD-63456

Single-particle
3.17 Å
EMD-63456
3D View Gallery
Deposition: 16/02/2025
Map released: 01/10/2025
Last modified: 01/10/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-63456

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9lwq summary report (pdf.gz) Map-9lwq FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Cryo-EM structure of PI3Kalpha in complex with compound UCL-TRO-1938

EMD-63456

Single-particle
3.17 Å
EMD-63456
3D View Gallery
Deposition: 16/02/2025
Map released: 01/10/2025
Last modified: 01/10/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Human PI3Kalpha in complex with 1938
Fitted models: 9lwq

Deposition Authors: Liu X, Zhou Q
Molecular mechanisms of PI3K alpha activation by small-molecule activator 1938 and cancer-specific mutation H1047R.
Liu X, Zhou Q, Chen Y, Han W, Li J, Mai Y, Wang MW
(2025) Cell Discov , 11 , 77 - 77
PUBMED: 40968123
DOI: doi:10.1038/s41421-025-00833-w
ISSN: 2056-5968