EMD-6340
Electron cryo-microscopy of a BRCA1-RNAPII transcriptional complex
EMD-6340
Single-particle22.0 Å
Deposition: 20/05/2015Map released: 04/05/2016
Last modified: 04/05/2016
Sample Organism:
Homo sapiens
Sample: BRCA1-RNAP II transcriptional assemblies isolated from hereditary breast cancer cells
Deposition Authors: Gilmore BL, Winton CE, Demmert AC, Tanner JR, Bowman S, Karageorge V, Patel K, Sheng Z, Kelly DF
Sample: BRCA1-RNAP II transcriptional assemblies isolated from hereditary breast cancer cells
Deposition Authors: Gilmore BL, Winton CE, Demmert AC, Tanner JR, Bowman S, Karageorge V, Patel K, Sheng Z, Kelly DF
A Molecular Toolkit to Visualize Native Protein Assemblies in the Context of Human Disease.
Gilmore BL,
Winton CE,
Demmert AC,
Tanner JR,
Bowman S,
Karageorge V,
Patel K,
Sheng Z,
Kelly DF
(2015) Sci Rep , 5 , 14440 - 14440
(2015) Sci Rep , 5 , 14440 - 14440
Secondary citations:
- Walmacq C, Cheung AC, Kireeva ML, Lubkowska L, Ye C, Gotte D, Strathern JN, Carell T, Cramer P & Kashlev M. (2012) Mechanism of translesion transcription by RNA polymerase II and its role in cellular resistance to DNA damage. Mol. Cell, 46, 18 - 29
- Brzovic PS, Rajagopal P, Hoyt DW, King MC & Klevit RE. (2001) Structure of a BRCA1-BARD1 heterodimeric RING-RING complex. Nat. Struct. Mol. Biol., 8, 833 - 837
- Williams RS, Green R & Glover JN. (2001) Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1. Nat. Struct. Mol. Biol., 8, 838 - 842
- Vijay-Kumar S, Bugg CE & Cook WJ. (1987) Structure of ubiquitin refined at 1.8 A resolution. J. Mol. Biol., 194, 531 - 544
- Gilmore BL, Winton CE, Demmert AC, Tanner JR, Bowman S, Karageorge V, Patel K, Sheng Z & Kelly DF. A Molecular Toolkit to Visualize Native Protein Assemblies in the Context of the Human Disease. Journal of Scientific Reports,
- Grunberg S, Warfield L & Hahn S. (2012) Architecture of the RNA polymerase II preinitiation complex and mechanism of ATP-dependent promoter opening. Nat. Struct. Mol. Biol., 19, 788 - 796