EMD-62849

Single-particle
2.9 Å
EMD-62849
3D View Gallery
Deposition: 23/12/2024
Map released: 31/12/2025
Last modified: 11/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-62849
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9l60 summary report (pdf.gz) Map and 9l60 FULL report (pdf.gz)
EMICSS annotations (xml)

Gi-bound kappa opioid receptor in complex with dynorphin and positive allosteric modulator MPAM-15

EMD-62849

Single-particle
2.9 Å
EMD-62849
3D View Gallery
Deposition: 23/12/2024
Map released: 31/12/2025
Last modified: 11/03/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Rattus norvegicus, Bos taurus
Sample: Quaternary complex of kappa opioid receptor coupled to Gi heterotrimer
Fitted models: 9l60

Deposition Authors: Zhuang Y, Wang Y, Xu Y, Luo P, Xu HE
Structure-based design of an opioid receptor modulator for enhanced morphine analgesia.
Wang Y, Luo P, Xu H, Zhan L, Sakamoto K, Li M, Wang J, Huang XP, Zhou J, Liu T, Suo Y, Fan W, He X, Xu Y, Cai Y, Wang C, Zhao Y, Dai A, Lai Y, Yuan Q, Hu W, Wu K, Yang D, Cheng X, Lu X, Krumm B, Kenakin T, Zhang J, Roth BL, Gao Z, Xu HE, Zhuang Y
(2026) Sci Adv , 12 , eaea9832 - eaea9832
PUBMED: 41671375
DOI: doi:10.1126/sciadv.aea9832
ISSN: 2375-2548