EMD-61470

Single-particle
2.93 Å
EMD-61470
3D View Gallery
Deposition: 08/09/2024
Map released: 23/04/2025
Last modified: 25/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-61470

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9jh3 summary report (pdf.gz) Map-9jh3 FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

CMF-019 with APLNR-Gi complex

EMD-61470

Single-particle
2.93 Å
EMD-61470
3D View Gallery
Deposition: 08/09/2024
Map released: 23/04/2025
Last modified: 25/06/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens, Mus musculus
Sample: APLNR-bound CMF-019 in complex with Gi heterotrimer
Fitted models: 9jh3

Deposition Authors: Tian XW, Zhao C, Feng YY, Shao ZH, Sun JP, Shao ZH, Sun JP
Multiscale biased chemical space remodeling for developing APLNR agonists with anti-HFpEF efficacy.
Sun Q , Tian X, Tan L , Deng Y , Liu S, Xiong Y , Feng Y , Wang Y, Zhang L, Zhu J, Xiao H, Shao Z , Guo Y, Yan W, Li T , Ouyang L
(2025) PNAS , 122 , e2423432122 - e2423432122
PUBMED: 40314976
DOI: doi:10.1073/pnas.2423432122
ISSN: 1091-6490
ASTM: PNASA6