EMD-61173
Complex I from respirasome closed state 1 bound by metformin and CoQ10 (SC-MetC1-iv)
EMD-61173
Single-particle2.92 Å
Deposition: 16/08/2024Map released: 19/11/2025
Last modified: 19/11/2025
Sample Organism:
Sus scrofa
Sample: Complex I from respirasome closed state 1 bound by metformin and CoQ10 (SC-MetC1-iv)
Fitted models: 9j6h
Deposition Authors: Teng F
,
He ZX ,
Hu YQ ,
Xu CY,
Guo RY,
Zhou L
Sample: Complex I from respirasome closed state 1 bound by metformin and CoQ10 (SC-MetC1-iv)
Fitted models: 9j6h
Deposition Authors: Teng F
,
He ZX ,
Hu YQ ,
Xu CY,
Guo RY,
Zhou L
Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms.
He Z,
Teng F ,
Yang Y,
Guo R,
Wu M,
Han F,
Tian H,
Wang J,
Hu Y,
Jiang Y,
Zhang L,
Xu C,
Yang F,
Zhou J,
Zhang S,
Letts JA,
Zhou R,
Zhou L
(2025) Nat Struct Mol Biol
,
Yang Y,
Guo R,
Wu M,
Han F,
Tian H,
Wang J,
Hu Y,
Jiang Y,
Zhang L,
Xu C,
Yang F,
Zhou J,
Zhang S,
Letts JA,
Zhou R,
Zhou L
(2025) Nat Struct Mol Biol
Grant Support:
- ZJU100 Young Professor: (China)