EMD-60425
Complex I form respirasome open state bound by proguanil (SC-ProgO)
EMD-60425
Single-particle3.1 Å
Deposition: 05/06/2024Map released: 17/12/2025
Last modified: 08/07/2026
Sample Organism:
Sus scrofa
Sample: Respirasome open state inhibited by proguanil
Fitted models: 8zsr
Deposition Authors: Teng F
,
He ZX,
Hu YQ,
Xu CY,
Guo RY,
Zhou L
Sample: Respirasome open state inhibited by proguanil
Fitted models: 8zsr
Deposition Authors: Teng F
,
He ZX,
Hu YQ,
Xu CY,
Guo RY,
Zhou L
Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms.
He Z ,
Teng F ,
Yang Y ,
Guo R,
Wu M,
Han F,
Tian H,
Wang J,
Hu Y ,
Jiang Y,
Zhang L,
Xu C,
Yang F,
Zhou J,
Zhang S,
Letts JA,
Zhou R ,
Zhou L
(2026) Nat Struct Mol Biol , 33 , 100 - 111
,
Teng F ,
Yang Y ,
Guo R,
Wu M,
Han F,
Tian H,
Wang J,
Hu Y ,
Jiang Y,
Zhang L,
Xu C,
Yang F,
Zhou J,
Zhang S,
Letts JA,
Zhou R ,
Zhou L
(2026) Nat Struct Mol Biol , 33 , 100 - 111
Grant Support:
- Other government: ZJU100 Young Professor (China)