Happy Holidays and New year from the EMDB! Please be advised that the EMDB team will be operating at reduced capacity between December 15th - January 12th. With this in mind we would ask that you be prepared for longer reply times through both our helpdesk system and the OneDep deposition system. well done on a productive 2025, wishing you all the best and we will see you in 2026!

EMD-60425

Composite map
Single-particle
3.1 Å
EMD-60425
3D View Gallery
Deposition: 05/06/2024
Map released: 17/12/2025
Last modified: 17/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-60425
Download
3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 8zsr summary report (pdf.gz) Map and 8zsr FULL report (pdf.gz)
EMICSS annotations (xml)

Complex I form respirasome open state bound by proguanil (SC-ProgO)

EMD-60425

Composite map
Single-particle
3.1 Å
EMD-60425
3D View Gallery
Deposition: 05/06/2024
Map released: 17/12/2025
Last modified: 17/12/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Sus scrofa
Sample: Respirasome open state inhibited by proguanil
Fitted models: 8zsr

Deposition Authors: Teng F , He ZX, Hu YQ, Xu CY, Guo RY, Zhou L

structural basis for inhibition of mammalian respirasome by metformin and proguanil
Teng F , He ZX, Yang YQ, Guo RY, Hu YQ, Xu CY, Zhou RH, Zhang X , Zhang S, Zhou L
To Be Published
Grant Support: