EMD-60418
Complex I from respirasome closed state 1 bound by metformin and CoQ10, alternative orientation (SC-MetC1-ii)
EMD-60418
Single-particle3.09 Å
Deposition: 05/06/2024Map released: 19/11/2025
Last modified: 04/02/2026
Sample Organism:
Sus scrofa
Sample: respirasome closed state 1 bound by metformin and CoQ(alternative orientation),comformation B
Fitted models: 8zsk
Deposition Authors: Teng F
,
He ZX,
Hu YQ,
Xu CY,
Guo RY,
Zhou L
Sample: respirasome closed state 1 bound by metformin and CoQ(alternative orientation),comformation B
Fitted models: 8zsk
Deposition Authors: Teng F
,
He ZX,
Hu YQ,
Xu CY,
Guo RY,
Zhou L
Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms.
He Z ,
Teng F ,
Yang Y ,
Guo R,
Wu M ,
Han F ,
Tian H ,
Wang J,
Hu Y ,
Jiang Y,
Zhang L,
Xu C,
Yang F ,
Zhou J ,
Zhang S ,
Letts JA ,
Zhou R ,
Zhou L
(2026) Nat Struct Mol Biol , 33 , 100 - 111
,
Teng F ,
Yang Y ,
Guo R,
Wu M ,
Han F ,
Tian H ,
Wang J,
Hu Y ,
Jiang Y,
Zhang L,
Xu C,
Yang F ,
Zhou J ,
Zhang S ,
Letts JA ,
Zhou R ,
Zhou L
(2026) Nat Struct Mol Biol , 33 , 100 - 111
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