EMD-60378

Single-particle
2.9 Å
EMD-60378
3D View Gallery
Deposition: 31/05/2024
Map released: 19/11/2025
Last modified: 19/11/2025
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-60378
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
EMICSS annotations (xml)

Cryo-EM map of respirasome closed state bound by proguanil (SC-ProgC), complex I distal membrane arm focused

EMD-60378

Single-particle
2.9 Å
EMD-60378
3D View Gallery
Deposition: 31/05/2024
Map released: 19/11/2025
Last modified: 19/11/2025
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Sus scrofa
Sample: Respirasome closed state inhibited by proguanil

Deposition Authors: Teng F , He ZX , Hu YQ , Xu CY, Guo RY, Zhou L
Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms.
He Z , Teng F , Yang Y , Guo R, Wu M , Han F , Tian H , Wang J, Hu Y , Jiang Y, Zhang L, Xu C, Yang F , Zhou J , Zhang S , Letts JA , Zhou R , Zhou L
(2025) Nat Struct Mol Biol
PUBMED: 41214295
DOI: doi:10.1038/s41594-025-01710-6
ISSN: 1545-9985