EMD-60362
Cryo-EM map of respirasome closed state 1 bound by metformin and CoQ, alternative orientation (SC-MetC1-iii), complex I peripheral arm focused
EMD-60362
Single-particle3.02 Å
Deposition: 31/05/2024Map released: 19/11/2025
Last modified: 04/02/2026
Sample Organism:
Sus scrofa
Sample: Respirasome closed state 1 bound by metformin and CoQ(alternative orientation), comformation B
Deposition Authors: Teng F
,
He ZX ,
Hu YQ ,
Xu CY,
Guo RY,
Zhou L
Sample: Respirasome closed state 1 bound by metformin and CoQ(alternative orientation), comformation B
Deposition Authors: Teng F
,
He ZX ,
Hu YQ ,
Xu CY,
Guo RY,
Zhou L
Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms.
He Z ,
Teng F ,
Yang Y ,
Guo R,
Wu M ,
Han F ,
Tian H ,
Wang J,
Hu Y ,
Jiang Y,
Zhang L,
Xu C,
Yang F ,
Zhou J ,
Zhang S ,
Letts JA ,
Zhou R ,
Zhou L
(2026) Nat Struct Mol Biol , 33 , 100 - 111
,
Teng F ,
Yang Y ,
Guo R,
Wu M ,
Han F ,
Tian H ,
Wang J,
Hu Y ,
Jiang Y,
Zhang L,
Xu C,
Yang F ,
Zhou J ,
Zhang S ,
Letts JA ,
Zhou R ,
Zhou L
(2026) Nat Struct Mol Biol , 33 , 100 - 111
Grant Support: