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EMD-60362
Cryo-EM map of respirasome closed state 1 bound by metformin and CoQ, alternative orientation (SC-MetC1-iii), complex I peripheral arm focused
EMD-60362
Single-particle3.02 Å
Deposition: 31/05/2024Map released: 19/11/2025
Last modified: 19/11/2025
Sample Organism:
Sus scrofa
Sample: Respirasome closed state 1 bound by metformin and CoQ(alternative orientation), comformation B
Deposition Authors: Teng F
,
He ZX ,
Hu YQ ,
Xu CY,
Guo RY,
Zhou L
Sample: Respirasome closed state 1 bound by metformin and CoQ(alternative orientation), comformation B
Deposition Authors: Teng F
,
He ZX ,
Hu YQ ,
Xu CY,
Guo RY,
Zhou L
Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms.
He Z,
Teng F ,
Yang Y,
Guo R,
Wu M,
Han F,
Tian H,
Wang J,
Hu Y,
Jiang Y,
Zhang L,
Xu C,
Yang F,
Zhou J,
Zhang S,
Letts JA,
Zhou R,
Zhou L
(2025) Nat Struct Mol Biol
,
Yang Y,
Guo R,
Wu M,
Han F,
Tian H,
Wang J,
Hu Y,
Jiang Y,
Zhang L,
Xu C,
Yang F,
Zhou J,
Zhang S,
Letts JA,
Zhou R,
Zhou L
(2025) Nat Struct Mol Biol
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