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EMD-60361
Cryo-EM map of respirasome closed state 1 bound by metformin and CoQ (SC-MetC1-ii), complex I distal membrane arm focused
EMD-60361
Single-particle2.82 Å
Deposition: 31/05/2024Map released: 19/11/2025
Last modified: 19/11/2025
Sample Organism:
Sus scrofa
Sample: respirasome closed state 1 bound by metformin and CoQ(alternative orientation), comformation A
Deposition Authors: Teng F
,
He ZX ,
Hu YQ ,
Xu CY,
Guo RY,
Zhou L
Sample: respirasome closed state 1 bound by metformin and CoQ(alternative orientation), comformation A
Deposition Authors: Teng F
,
He ZX ,
Hu YQ ,
Xu CY,
Guo RY,
Zhou L
Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms.
He Z ,
Teng F ,
Yang Y ,
Guo R,
Wu M ,
Han F ,
Tian H ,
Wang J,
Hu Y ,
Jiang Y,
Zhang L,
Xu C,
Yang F ,
Zhou J ,
Zhang S ,
Letts JA ,
Zhou R ,
Zhou L
(2025) Nat Struct Mol Biol
,
Teng F ,
Yang Y ,
Guo R,
Wu M ,
Han F ,
Tian H ,
Wang J,
Hu Y ,
Jiang Y,
Zhang L,
Xu C,
Yang F ,
Zhou J ,
Zhang S ,
Letts JA ,
Zhou R ,
Zhou L
(2025) Nat Struct Mol Biol
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