EMD-60358

Single-particle
3.21 Å
EMD-60358
3D View Gallery
Deposition: 31/05/2024
Map released: 19/11/2025
Last modified: 04/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-60358
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EMICSS annotations (xml)

Cryo-EM map of respirasome closed state 1 bound by metformin alone (SC-MetC1-i), complex I distal membrane arm focused

EMD-60358

Single-particle
3.21 Å
EMD-60358
3D View Gallery
Deposition: 31/05/2024
Map released: 19/11/2025
Last modified: 04/02/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Sus scrofa
Sample: Respirasome closed state 1 bound by metformin alone

Deposition Authors: Teng F , He ZX , Hu YQ , Xu CY, Guo RY, Zhou L
Hydrophilic metformin and hydrophobic biguanides inhibit mitochondrial complex I by distinct mechanisms.
He Z, Teng F , Yang Y, Guo R, Wu M, Han F, Tian H, Wang J, Hu Y, Jiang Y, Zhang L, Xu C, Yang F, Zhou J, Zhang S, Letts JA, Zhou R, Zhou L
(2026) Nat Struct Mol Biol , 33 , 100 - 111
PUBMED: 41214295
DOI: doi:10.1038/s41594-025-01710-6
ISSN: 1545-9985